Fluralaner works primarily by interfering with GABA-gated chloride channels, similar to the targets of insecticides such as cyclopentadienes, phenylpyrazoles, and macrolides. Fluralaner is a broad-spectrum insecticide with good insecticidal activity against pests such as ticks, fleas, lice, hemiptera and diptera, and its virulence is higher than or comparable to commonly used insecticides . Fluralaner not only has no significant cross-resistance with existing insecticides, but also has good insecticidal activity against some resistant pests.